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Pituitary Gland Malfunction

The pituitary gland is about the size of a peanut and sits at the bottom of the brain. It’s known commonly as the “master gland”, because it controls other glands in the body and regulates several bodily functions like growth, reproduction, and stress reactions through hormones, slow-acting chemical messengers. When the pituitary gland malfunctions, it either overproduces or under produces the hormones that it controls, causing a wide range of reactions.

Pituitary gland malfunction can be severe or mild, and often goes undiagnosed or misdiagnosed because the symptoms can mimic so many other diseases. These are the hormones the pituitary gland are responsible for responding to disease, controlling blood pressure, releasing eggs in women and sperm in men, pregnancy, regulating growth of the body and metabolism, breast milk production, and regulating the amount of water in the body.

When the pituitary gland malfunctions and is overactive or underactive, growth can be stunted or sped up, the ability to have children may be at risk, and everyday functions such as maintaining a normal blood pressure may be difficult to manage.

Symptoms

Common symptoms of pituitary gland malfunction include:

  • Hair loss
  • Anxiety or depression
  • Diabetes
  • High blood pressure
  • Vision changes
  • Breast milk production, even if not a new mother
  • Lack of energy
  • Abnormal menstrual periods
  • Lack of growth or unusually fast growth
  • Weight gain

Causes & Risk Factors

The main cause of pituitary gland malfunction is a benign tumour on the pituitary gland. Other common causes include a head injury, bleeding near the pituitary gland, and radiation therapy.

Risk factors for pituitary gland malfunction include genetic conditions like:

  • Multiple endocrine neoplasia, type I (MEN I) – this is a condition in which one experiences several benign tumour growths on glands that secrete hormones, like the pituitary gland
  • Familial isolated pituitary adenoma – benign tumour that grows on the pituitary gland

People of either sex can develop pituitary gland malfunction at any age.

Diagnosis & Complications

In addition to taking a thorough medical history and a physical exam, a medical professional will run some specialised tests to determine pituitary gland malfunction. These include blood and urine tests to measure the level of hormones in your body, as well as dynamic tests that are designed to raise or lower the levels of certain hormones. If those hormones don’t respond as expected, it indicates some kind of pituitary malfunction. Magnetic resonance imaging (MRI) technology can also be used to detect the presence of benign tumours.

Complications of pituitary gland malfunction include:

  • Acromegaly – disorder that involves too much growth in the face and hands
  • Empty sella syndrome – this is noted by a shrinking of a bony structure near the pituitary gland. It does not always have symptoms, but when it does, they can include feelings of helplessness, low libido, and in women, abnormal menstruation
  • Diabetes insipidus – very different from type 1 or type 2 diabetes, diabetes insipidus happens when the kidneys cannot keep enough water in the body. As a result, you always feel thirsty and have to urinate often.
  • Vision loss – the pituitary gland is close enough to the nerves of the eye that if a tumour is growing, it may press on the optic nerve and cause partial or complete vision loss.

Treatment & Management

Pituitary gland malfunction can be treated in a variety of ways. Often medication is used to replace hormones, if the pituitary gland is under producing, or to suppress hormones if it is over producing. Treatment of any vision loss is included in a treatment plan for someone with pituitary gland malfunction, if that’s something they have experienced. Additionally, surgery and radiation therapy can be used to eliminate the benign tumours causing the malfunction.

While there is no instant cure or way to prevent pituitary gland malfunction, you can have a high quality of life living with it and managing it.

 
 
 

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