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Hypersplenism

Your spleen plays a very crucial role in removing toxins from your blood. When a spleen becomes enlarged, which often results from some other medical condition, you may experience hypersplenism. This condition causes the organ to become overactive, which leads to a loss of healthy blood cells.

Treatment of Hypersplenism Depends on the Underlying Cause

Hypersplenism usually follows splenomegaly, which is also known as spleen enlargement. Spleen enlargement typically results from some other medical condition or disorder, and treating these conditions can sometimes resolve issues with spleen overactivity. Here are some common causes of splenomegaly and how medication can help address them:

  • Infections – The spleen can sometimes become inflamed due to infections, which may result from bacteria, viruses, or parasites. Medications (such as antibiotics for bacterial infections) can be used to treat these issues and prevent health effects from impacting the spleen. 
  • Liver Disease – Medications like ursodiol can slow the progression of cirrhosis, a liver disease that causes the organ to develop scar tissue. Antiviral medications can also be used to treat chronic hepatitis, another condition that can damage the liver. 
  • Autoimmune Disorders – Splenomegaly is also linked to autoimmune conditions like lupus. In this case, non-steroidal anti-inflammatory drugs, corticosteroids, and immunosuppressants may be recommended. 
  • Cancer – When spleen enlargement is linked to certain types of cancer, chemotherapy and targeted drugs may be used to eliminate cancerous cells in the body.

By addressing these underlying health issues, doctors hope to restore the normal function of the spleen.

Other Treatments May Also Be Recommended

In addition to medication, people experiencing splenomegaly/hypersplenism may also need blood transfusions to ensure a sufficient amount of blood cells. If symptoms are severe and other treatments aren’t getting the desired results, doctors may recommend removing the spleen (a procedure known as splenectomy). After the surgery, many patients need to take a daily antibiotic for life to ward off illness due to the spleen’s impact on immune function.

 
 
 

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