Also called APS-1 and APECED, autoimmune polyglandular syndrome type 1 is a genetic disorder that causes numerous symptoms. APS-1 can affect multiple organs and make a person more vulnerable to candidiasis, which is a type of fungal infection.
People with APS-1 will experience repeated bouts of candidiasis, which is characterized by symptoms like oral thrush, skin rashes, and yeast infections. Health problems associated with APS-1 can vary greatly thanks to the widespread effects of the disorder. Possible symptoms include low blood pressure, cramping, seizures, chronic digestive issues, inflammation of internal organs, and other effects.
Treatment typically depends on the type of symptoms a person with APS-1 is experiencing. Antifungal medications are effective against candidiasis, while endocrine issues can be treated with hormone therapy. Doctors may also recommend increased intake of vitamin D and calcium.
To control the faulty immune response, patients may receive immunosuppressive medications. These drugs stop the immune system from attacking healthy tissues, such as the internal organs.
Many people with APS-1 go on to have a good prognosis. However, the effects of the condition can vary quite a bit, so experiences can also vary from person to person. The condition can also be progressive, meaning that new symptoms may emerge over time. Accordingly, many individuals require lifelong management of APS-1.