Microbiome Imbalance and
Endometrial Cancer Risk

How Does the Endometrial Microbiome Affect Your Cancer Risk?

In the past, medical researchers believed that the uterus was a sterile environment. However, ongoing study has determined that the uterus harbours bacteria, much like the gut. “Good” bacteria help maintain a healthy environment, which establishes a sound foundation for pregnancy and general wellness.

In some people, bacteria within the uterus and gut can become imbalanced, and it’s believed that these imbalances may increase one’s risk of developing endometrial cancer. One possible theory is that microbiome imbalances contribute to inflammation, which then negatively affects a person’s health. However, it must be noted that more research is needed to determine the exact link between imbalanced microbiome and endometrial cancer risk.

Other Risk Factors for Endometrial Cancer

Along with imbalances of the endometrial microbiome, there are other factors that may increase your risk of developing endometrial cancer. These risk factors include:

• Use of a breast cancer drug called tamoxifen
• Undergoing oestrogen-based hormone replacement therapy
• Lack of pregnancies during one’s lifetime
• Experiencing early menstruation and late menopause
• Having metabolic syndrome
• Being obese
• Experiencing medical conditions like polycystic ovary syndrome

If one or more of these risk factors apply to you, talk with your doctor about endometrial cancer. There are steps you can take, such as regular exercise, that may decrease your risk.