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Lymphogranuloma Venereum
(LGV)

A sexually transmitted disease (STD), lymphogranuloma venereum (LGV) is caused by 3 different types of the bacterium Chlamydia trachomatis. A different strain of the bacterium C. trachomatis causes the commonly known STD chlamydia. LGV has 3 stages and is most commonly diagnosed in men. Men usually show symptoms before women do.

LGV is common to certain parts of the world, such as India, Southeast Asia, South America, the Caribbean, and East and West Africa. However, outbreaks of LGV have appeared in North America, Europe, and Australia in recent years in the population of men having sex with men.

Symptoms

Symptoms of LGV usually begin to appear 3 days after initial infection. However, they can appear as late as 30 days after infection. There are 3 stages of LGV, each one with its own set of symptoms.

The only symptom during the first stage is tiny, painless blisters on the penis or the vagina. They heal very quickly. One may also experience sores in the mouth.

The second stage occurs anywhere from 2-6 weeks after the end of the first stage. Symptoms can include:

  • Build-up of lymph fluid in the genital area and in the rectum for women
  • Build-up of lymph fluid in the groin for men (buboes)
  • Breakdown of skin over the fluid build-up, allowing fluid to drain
  • Constipation
  • Fatigue
  • Pain in the abdomen, anus, and back and pelvis for women
  • Muscle aches
  • Headache
  • Fever
  • Difficulty urinating
  • Weight loss
  • Bleeding from the rectum
  • Difficulty having a bowel movement
  • Irritation of the anus and rectum
  • Constant feeling like you need to have a bowel movement

LGV will progress to the third stage without proper treatment at the first and second stages. Symptoms of the third stage include:

  • Abscesses – pockets of pus- where there was fluid build-up
  • Deformed genitals
  • A narrowing of the rectum that can make it hard to have a bowel movement
  • Genital swelling
  • Anal fistula – small channel connecting an abscess inside the anus to a skin lesion outside the anus. These can be very painful.
  • Pelvic floor dysfunction – this condition leads to an inability to correctly use the muscles in the pelvis. This can look like having difficulty passing a bowel movement, trouble urinating, pain during sexual intercourse, and erectile dysfunction if you are a male.

Causes & Risk Factors

There are 3 strains of the C. trachomatis bacterium that can cause LGV. It only takes contact with 1 strain to cause LGV. The bacterium is transmitted via sexual contact with an infected person. This can include vaginal penetration, anal sex, or oral sex.

Risk factors for LGV include:

  • Having multiple sexual partners
  • Having an HIV+ diagnosis
  • Being a man who has sex with men
  • Being sexually active between the ages of 15 and 40

Diagnosis & Complications

Your doctor will get a medical history and do a physical examination. If they suspect you may have LGV based on your past and current symptoms and physical examination, they will order tests for confirmation.

They may order a blood test to look for proteins the immune system produces to fight infection. They may also swab the vagina, penis, rectum, or take a sample of any fluid that is leaking through the skin. Your doctor will look for the C. trachomatis bacterium strains that cause LGV in this sample.

Complications of LGV are usually seen in the 3rd stage of the disease and result from LGV being undiagnosed or untreated. They include:

  • Scarring in the groin and genital area
  • Severe pain
  • Scarring around the rectum
  • Permanent narrowing of the rectum, leading to lifelong difficulty having a bowel movement
  • Genital swelling
  • Blockage of lymph fluid in the lymphatic system
  • Infertility
  • Joint disease due to long-term, untreated infection (reactive arthropathy)

Treatment & Management

LGV is treated with antibiotics. Your doctor may also suggest trying a biopsy of any places in the genital area with fluid build-up. This can help relieve associated symptoms and prevent complications. For people with severe LGV, surgery may be necessary.

 
 
 

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