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Beriberi

Beriberi is a disease caused by a thiamine deficiency (vitamin B1). Thiamine is an essential nutrient that plays a crucial role in the metabolism of carbohydrates and the proper functioning of the nervous system.

Beriberi is most commonly seen in populations that rely heavily on polished rice as a staple food, as the milling process removes most of the thiamine content from the grain. Alcoholism, malnutrition, and gastrointestinal diseases that impair thiamine absorption can also lead to beriberi.

Symptoms

South Africa has a history of Beriberi outbreaks because of severe thiamine deficiency due to diet and access to thiamine rich foods. Though the symptoms may be different depending on the disease type, some common signs include the following:

  • Weakness and Fatigue: One of the most common symptoms of beriberi is weakness and fatigue, which can be severe enough to interfere with daily activities.
  • Tingling and Numbness: Beriberi can cause a loss of sensation in the hands and feet, leading to tingling and numbness.
  • Muscle Pain: Muscle pain and tenderness can also occur, especially in the legs.
  • Difficulty Walking: Beriberi can affect the nerves that control muscle movement, leading to difficulty walking and losing balance.
  • Rapid Heartbeat: Beriberi can cause an abnormally fast heartbeat, which can lead to heart failure in severe cases.
  • Shortness of Breath: Shortness of breath can occur due to heart failure or fluid accumulation in the lungs.

Only in severe cases, does beriberi can lead to heart failure, swelling of the legs and feet, and even death.

Causes

Generally, beriberi has two main conditions: wet and dry beriberi. Wet beriberi affects people’s cardiovascular system, whereas dry beriberi impacts the nervous system. A deficiency of thiamine in the diet is one of the main causes of beriberi. It is more common in parts of the world where processed; unenriched white rice doesn’t have enough thiamine.  Thiamine is mostly found in whole-grain and enriched grain products.

Risk Factors

Certain factors can make you prone to develop thiamine deficiency. These may include:

  • Alcohol misuse (low thiamine absorption)
  • AIDS
  • Hyperthyroidism (overactive thyroid glands)
  • Malnutrition
  • Prolonged diarrhoea
  • Bariatric surgery
  • Kidney dialysis
  • Diabetes

Diagnosis & Complications

Some blood tests and physical exams are required to measure thiamine levels in the blood.

Your doctor may also ask about your medical history, including dietary or alcohol intake habits.

However, if the disease isn’t diagnosed on time, it can lead to some complications, including:

  • Cardiovascular Complications: Beriberi increases the risk of heart failure, which can be life-threatening. The condition can also lead to an irregular heartbeat or arrhythmia.
  • Peripheral Neuropathy: Beriberi can damage the nerves that control movement and sensation in the limbs, leading to peripheral neuropathy.
  • Wernicke-Korsakoff syndrome is a severe neurological disorder that can occur due to thiamine deficiency, particularly in chronic alcoholics. Symptoms include confusion, memory loss, and difficulty with coordination.
  • Beriberi encephalopathy: This is a rare but severe form of beriberi that affects the brain and can lead to seizures, coma, and even death.
  • Infantile beriberi: Babies born to mothers with thiamine deficiency can develop infantile beriberi, which can cause heart failure, difficulty feeding, and respiratory distress.

Treatment & Prevention

Treatment for beriberi typically involves thiamine supplementation through oral or injectable forms, depending on the severity of the condition. The dosage and duration of treatment will depend on the individual’s age, weight, and the severity of their symptoms.

In addition to thiamine supplementation, a diet rich in thiamine-containing foods, such as whole grains, legumes, and nuts, can also help prevent and manage beriberi. Prevention of beriberi involves ensuring consumption of a well-balanced diet that includes a variety of nutrient-dense foods to ensure adequate thiamine intake.

 
 
 

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