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Disorders of Protein Digestion

Protein digestion disorders refer to conditions affecting the body’s ability to break down and absorb protein. Proteins are essential macronutrients that provide the building blocks for tissues, enzymes, hormones, and other important molecules in the body.

Some other common disorders of protein digestion include:

  • Pancreatic Insufficiency: Low enzyme production can cause malnutrition; particularly for proteins. Individuals who have chronic cystic fibrosis or cancer are at higher risk of developing this.
  • Celiac Disease: This autoimmune disorder triggers immunity and affects the function of the small intestine. As a result, you may suffer from protein deficiency.
  • Peptic Ulcer Disease: The disease is a condition that affects the stomach lining and can interfere with the digestion of proteins.

Symptoms

In several developing countries like South Africa, the percentage of protein intake has dropped significantly, resulting in malnutrition.

The symptoms can greatly vary depending on your disorder type, as they are digestion disorders. However, the following are some symptoms most people with protein digestion disorder experience.

  • Stomach-ache
  • Bloated stomach
  • Nauseous feeling
  • Diarrhoea or constipation
  • Weight loss or growth issues in children
  • Fatigue or weakness
  • Anaemia (low red blood cell count)
  • Loss of muscle
  • Oedema (swelling due to fluid accumulation)
  • Nutrient deficiencies, such as low levels of protein, vitamin B12, or iron

These symptoms are not specific to protein digestion disorders and can also be caused by many other conditions.

Causes

Generally, these disorders may have various hereditary and environmental causes including:

  • Enzyme Deficiencies

As mentioned earlier, the pancreas produces enzymes needed to break down protein. A deficiency in these enzymes can result in the malabsorption of protein and lead to protein digestion disorders.

  • Autoimmune Disorders

Celiac disease is an example of an autoimmune disorder that can affect protein digestion. High gluten eating may trigger an immune response in the small intestine.   This response can cause malabsorption of nutrients, including protein.

  • Gastrointestinal Surgery

Surgery involving the gastrointestinal tract removes a part of the small intestine. This affects the body’s ability to absorb protein and other nutrients.

  • Chronic Infections

Certain chronic infections (H. pylori or parasitic infections) can cause inflammation in the digestive tract, interfering with protein absorption.

Risk Factors

Genetics can be a risk factor as some protein digestion disorders are caused by genetic mutations that affect the production of digestive enzymes, such as cystic fibrosis or hereditary pancreatitis.  People who have had gastrointestinal surgery, especially involving the stomach or small intestine, are at increased risk of developing protein digestion disorders.

Age and lifestyle choices can also play a role in developing disorders of protein digestion.

Diagnosis & Complications

The healthcare professional may conduct blood tests to check for protein levels in the blood, stool tests to evaluate for malabsorption of protein, and imaging studies such as CT scans or MRIs to evaluate the gastrointestinal tract.

Endoscopic procedures such as an upper endoscopy, colonoscopy, or biopsy may also be necessary to further evaluate the digestive tract and confirm a diagnosis.

If timely treatment isn’t taken for disorders of protein digestion, the result will be malnutrition, weight loss, weakness, and anaemia.

Treatment & Prevention

People with pancreatic insufficiency may benefit from taking digestive enzyme supplements with their meals to aid in protein digestion.

Moreover, a healthcare professional or dietitian can recommend a high-protein, low-fat diet that is easy to digest and absorb. Avoiding processed and high-fat foods, as well as limiting or eliminating alcohol and caffeine, may also help prevent the disorders.

 
 
 

The content appearing on this site is not intended to treat, diagnose, or provide health care advice. The articles you read here are meant for informational purposes only. Please review additional information to learn more.